References

Key scientific papers and implementation references used in this application.

This web-based tool is publicly available at www.hdrisktool.org.

1. Langbehn DR, Brinkman RR, Falush D, Paulsen JS, Hayden MR. A new model for prediction of the age of onset and penetrance for Huntington's disease based on CAG length.
   Clin Genet. 2004;65(4):267-277.
   Open source
2. Long JD, Paulsen JS, Marder K, et al. Validation of a prognostic index for Huntington disease.
   Mov Disord. 2017;32(2):256-263.
   Open source
3. Langbehn DR, et al. Utility of the Huntington's Disease Prognostic Index Score for a Perimanifest Clinical Trial.
   Mov Disord Clin Pract. 2022.
   Open source
4. Warner JH, et al. Standardizing the CAP Score in Huntington's Disease by Predicting Age-at-Onset.
   J Huntingtons Dis. 2022.
   Open source
5. Edward Wild's Huntington's disease conditional onset probability calculator
   Implementation reference / spreadsheet calculator
   Open source

For clinician / clinician-scientist use only. This application provides model-based estimates for educational and research support and should not be used as a standalone basis for diagnosis, prognosis, or patient counseling.